Webb6 mars 2024 · These findings seem to confirm the Pedersen hypothesis, which postulated that maternal hyperglycemia is transferred to the fetus, causing an exaggerated fetal insulin response . The resulting fetal hyperinsulinemia is thought to cause various aspects of diabetic fetopathy, including the deposition of large amounts of body fat. Webb14 nov. 2015 · Study Rundown: The Pedersen hypothesis, postulated by Jorgen Pedersen in 1952, states that maternal hyperglycemia leads to fetal hyperglycemia, invoking an exaggerated production of insulin in the neonate. This increased insulin production acts as a fetal growth factor and contributes to metabolic derangements after delivery.

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WebbCatalano PM, Hauguel-De Mouzon S. Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic? Am J Obstet Gynecol 2011;204:479–87. Brisson D, Perron P, Kahn HS, Gaudet D, Bouchard L. The lipid accumulation product for the early prediction of gestational insulin resistance and glucose dysregulation. Webb30 nov. 2009 · I herein put forward the hypothesis that physical inactivity leads to accumulation of visceral fat and consequently the activation of a network of inflammatory pathways, which promote development of insulin resistance, atherosclerosis, neurodegenation and tumour growth, and thereby the development of the diseases … novel andrea hirata pdf

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WebbFreinkel evaluated the Jørgen Pedersen hyperglycemia-hyperinsulinism hypothesis in the next section of the article. The Pedersen hypothesis suggests that fetal overgrowth is related to the glucose transported from the mother to the placenta [10], which then stimulates the release of insulin by the fetal cells. WebbTorben Pedersen is professor of International Business at Copenhagen Business School. His research interests is in the interface between strategy and international management and he has published over 100 articles and books concerning the managerial and strategic aspects of globalization. His research has appeared in prominent journals such as ... WebbPedersen [8] suggested already in 1952 that maternal hyperglycemia transmits to the fetus and induce fetal hyperinsuline-mia that stimulates growth and leads to increased birth weight and excessive body fat in the offspring [8]. In concordance with the Pedersen hypothesis, maternal glucose is associated with birth weight [9-11]. Also, novel anna and the king of