Diacylglycerol kinases in cancer

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August undefined, 2024

WebMar 1, 2024 · Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. WebAug 24, 2015 · PA-generating enzyme expression and/or activity could thus provide a basis for cancer therapies. Diacylglycerol kinase-ζ (DGKζ) is a DGK family enzyme that, by phosphorylating diacylglycerol ...

Diacylglycerol kinase α inhibition cooperates with PD-1-targeted ...

WebFeb 28, 2024 · Thus, diacylglycerol kinases constitute a critical node in signal transduction and a fascinating target for novel therapies. In particular, the increasing number of proteins that are known to be regulated either by diacylglycerol or by phosphatidic acid maintain the great interest in those enzymes. ... DGKs control cancer cell survival ... WebOct 13, 2024 · C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes, are present in multiple signaling … chrome use high cpu

Protein kinase C and other diacylglycerol effectors in …

WebJan 1, 2024 · Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα … WebNov 15, 2015 · DGKα is one of 10 DGK family members that convert diacylglycerol (DAG) to phosphatidic acid (PA), and both DAG and PA are critical lipid second messengers in … WebApr 13, 2024 · In addition to activating the NF-κB pathway, protein kinase Cβ and diacylglycerol stimulate mitogen-activated protein kinase signalling, leading to activation and nuclear translocation of ... chrome user data folder

Diacylglycerol kinases in cancer - ScienceDirect

Downregulation of Diacylglycerol kinase zeta (DGKZ) …

WebJun 13, 2013 · After its generation, DAG is actively metabolized into phosphatidic acid by one of the 2 isoforms of diacylglycerol kinases (dgk) present within T cells, dgkα or dgkζ . Previously, we and others observed that deletion of either dgk isoform potentiates DAG-mediated Ras and extracellular signal-regulated kinase (ERK) activation and augments … WebRNA polymerase II (also called RNAP II and Pol II) is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. In humans, RNAP II consists of seventeen protein molecules (gene products encoded by POLR2A-L, where the proteins synthesized from POLR2C, POLR2E, and … chrome use proxyWebstructure summary. Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing … chrome user data folder copy

"WebJul 17, 2024 · The α‐isozyme of diacylglycerol kinase (DGK) enhances cancer cell proliferation and, conversely, it promotes the nonresponsive immune state known as T‐cell anergy. ... Diacylglycerol kinases ... " - Diacylglycerol kinases in cancer

Diacylglycerol kinases in cancer

The Roles of Diacylglycerol Kinase α in Cancer Cell ... - MDPI

WebApr 1, 2024 · Diacylglycerol kinases in cancer. Advances in Biological Regulation, Volume 63, 2024, pp. 22-31. Show abstract. Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα and ζ limit the activation of the PLCγ/Ras/ERK axis, providing a … Web1 Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; E-Mail: [email protected] ... Abstract: Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacylglycerol (DAG), a crucial second messenger of receptor-mediated ...

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WebAug 24, 2015 · PA-generating enzyme expression and/or activity could thus provide a basis for cancer therapies. Diacylglycerol kinase-ζ (DGKζ) is a DGK family enzyme that, by phosphorylating diacylglycerol ... WebJan 1, 2024 · The Diacylglycerol kinases (DGK) limit DAG-dependent functions in T lymphocytes and their upregulation in tumor-infiltrating T lymphocytes contribute to limit T cell cytotoxic potential. DGK blockade could reinstate T cell attack on tumors, limiting at the same time tumor cell growth, thanks to the DGK positive input into several oncogenic ...

WebDiacylglycerol (DAG) is an important lipid that both is an intermediate in lipid biosynthetic pathways and can act as a signaling lipid. The majority of signaling DAG is generated by … WebMar 14, 2024 · Diacylglycerol dictates the intracellular localization of PKD1, while PKC activates it by phosphorylation . PKD1 served as a tumor suppressor in advanced prostate cancer, where its expression was downregulated; later, it was found that it interacted with E-cadherin (180, 181). PKD1 interacts with β-catenin and phosphorylates it on Thr112 and ...

WebMar 1, 2016 · The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα …

WebDiacylglycerol kinases in cancer. @article{Mrida2024DiacylglycerolKI, title={Diacylglycerol kinases in cancer.}, author={Isabel M{\'e}rida and Pedro Torres-Ayuso and Antonia {\'A}vila-Flores and Javier Arranz-Nicol{\'a}s and Elena Andrada and Mar{\'i}a Tello-Lafoz and Rosa Liebana and Raquel Arcos}, journal={Advances in …

WebOct 17, 2016 · Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα, and DGKζ, specifically regulate the pool of DAG that is ... chrome user-agent client hints 关闭WebFeb 1, 2024 · Abstract. Diacylglycerol (DG) kinase (DGK) phosphorylates DG to generate phosphatidic acid (PA). The α isozyme is activated by Ca 2+ through its EF-hand motifs … chrome user data folder sizeWebJul 1, 2024 · Abstract. Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through phosphorylation of the ubiquitous secondary messenger diacylglycerol. Emerging clinical evidence supports DGK-alpha (DGKA) as a promising target for cancer immunotherapy because of its critical role in … chrome user manualWebNov 12, 2015 · Abstract. Lipid kinases have largely been neglected as targets in cancer, and an increasing number of reports suggest diacylglycerol kinase alpha (DGKα) may … chrome user script handlerWebDiacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, and its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. chrome user profile folder custom locationWebDiacylglycerol kinase zeta (DGKZ) belongs to the diacylglycerol kinase (DGK) family which catalyzes diacylglycerol (DAG) into phosphatidic acid (PA) [Citation 5]. PA production is the initiation of PtdInsP2 supplement in ‘PtdIns cycle’, which provides a lipid substrate, either for effects of phospholipase C (PLC) hydrolysis or for PtdIns 3 ... chrome users in worldWebOct 4, 2024 · Diacylglycerol kinases (DGKs) are multi-domain lipid kinases that phosphorylate diacylglycerol into phosphatidic acid, modulating the levels of these key signaling lipids. Recently, increasing attention has been paid to DGKα isozyme as a potential target for cancer immunotherapy. chrome use system print dialog