Cisplatin induced hypocalcemia

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August undefined, 2024

WebMar 9, 2024 · Cisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian cancer [1]. However, nephrotoxicity is the … WebBoldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3

Chemotherapy-Induced Hypocalcemia - Endocrine Practice

WebEven after correction of hypomagnesemia and hypocalcemia by magnesium repletion, hypokalemia persisted. Hypokalemia as a consequence of magnesium deficiency is well … WebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The … farm cove takeaways

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WebFeb 17, 2024 · A number of drugs sometimes cause hypocalcemia as a side effect. Some of these include the following: Certain drugs for osteoporosis ( bisphosphonates like zoledronate) 5 Some antiepileptic drugs Certain chemotherapy drugs (like cisplatin) Diuretic drugs (like furosemide) 6 Proton pump inhibitors WebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia. * hypomagnesemia. … WebHypomagnesemia is a common side effect of cisplatin occurring . in 90% of patients by the fourth cycle of treatment caused by renal tubular damage leading to increased renal … farm cover crops

A RANKL Wrinkle: Denosumab-Induced Hypocalcemia

Hypomagnesemia– A Toxicity of Platinum Co-Ordination …

WebCisplatin-induced hypomagnesemia with seizures: a case report and review of the literature Gynecol Oncol. 1988 May;30(1):104-13. doi: 10.1016/0090-8258(88)90052-2. Authors S L Bellin 1 ... Hypocalcemia / chemically induced Hypokalemia / … free online grade assessment testWebSep 4, 2009 · It should be noted that cisplatin causes hypocalcemia in a dose-dependent manner. Indeed, hypocalcemia is a frequent adverse effect of high-dose cisplatin … free online gpu for gaming

"WebMay 10, 2006 · Hypomagnaesemic induced hypocalcaemia is caused by inhibition of parathyroid hormone secretion, impaired calcium release from the bones and low tissue responses to PTH due to low magnesium levels. Cisplatin associated hypocalcaemia and hypercalciuria can not be influenced by calcium supplementation. " - Cisplatin induced hypocalcemia

Cisplatin induced hypocalcemia

Hypophosphatemia in cancer patients - Oxford Academic

WebMay 24, 2006 · Cisplatin is the most commonly used antineoplastic agent for the treatment of solid tumors and is a well-known cause of nephrotoxicity [ 1 ]. In this study we report a case with chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria 20 years after the initial treatment with cisplatin therapy. http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf

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WebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia * hypomagnesemia *hypocalcemia *hypophosphatemia *fanconi-like syndrome * acute kidney injury We have all seen these complications on the renal consult service at least once. WebJan 12, 2024 · There are two major mechanisms by which hypomagnesemia can be induced: gastrointestinal or renal losses . Regardless of the cause, hypomagnesemia …

WebNov 7, 2012 · The cisplatin-induced increase of the Kim-1 expression level suggests that the PST segment is also affected in our study [30, 44]. The NHE3 expression levels were similar in the kidneys of control and cisplatin-treated groups. ... Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the … WebDec 26, 2024 · Phosphate is one of the most important molecular elements to normal cellular functions within the body. It acts as an integral component of nucleic acids and is used to replicate DNA and RNA. It is an energy …

WebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management. Platinum chemotherapy, particularly cisplatin, is commonly associated with … WebMar 17, 2016 · It is likely that cisplatin contributed to the profound hypocalcemia in this patient, who presented with a serum Mg of 0.7 mg/dL. Denosumab, a monoclonal …

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WebApr 5, 2024 · In severe hypocalcemia, IV calcium is used initially, with transition to oral calcium. For mild hypocalcemia, oral calcium could be used for initial treatment. 1 gram … free online gradebook and attendanceWebApr 5, 2024 · causes of hypocalcemia Severe inflammation (sepsis, major burns). Pancreatitis (especially: hypertriglyceridemic pancreatitis). Citrate (massive transfusion, plasmapheresis, leukapheresis, renal replacement therapy). Ethylene glycol poisoning. Alkalosis: Respiratory alkalosis (e.g., panic-induced). farm coversWebB–induced hypomagnesemia. CASE SUMMARY: A 21-year-old man with β-thalassemia was treated with amphotericin B for Candida albicans intravenous line sepsis. After five days of treatment (cumulative dose 160 mg), he developed hypomagnesemia, which caused hypoparathyroidism and hypocalcemia; all three abnormalities resolved after the drug … free online gradebook for schoolsWebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … free online gps systemWebJul 19, 2024 · Usually, the hypocalcemia is resistant to calcium or vitamin D therapy. Normocalcemia and relief of clinical symptoms can be attained by administration of high oral doses of magnesium, up to 20 times the normal intake. ... Cisplatin- and amphotericin B–induced magnesium deficiency is associated with hypocalciuria, which suggests … free online grading scaleWebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose‐dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The etiology of cisplatin‐induced hypomagnesemia is not completely understood; renal Mg loss is the primary mechanism, but gastrointestinal losses have also been reported. 80 ... farm cowboyWebJan 12, 2024 · Hypomagnesemia is often associated with hypokalemia (due to urinary potassium wasting) and hypocalcemia (due both to lower parathyroid hormone secretion and end-organ resistance to its effect). (See "Hypomagnesemia: Clinical manifestations of magnesium depletion" .) The major causes of hypomagnesemia will be reviewed in this … farm cove school