Cinnamic acid and autophagy
WebDec 24, 2024 · Chlorogenic acid (CGA) , a phenolic compound produced by the esterification of cinnamic acid and (-)-quinic acid, is widely found in vegetables, fruits, and plants; a main ... J.G. 5-O-Demethylnobiletin alleviates CCl 4-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy induction. Int. J. Mol. WebWe have investigated the anti-inflammatory effects of Cinnamomum cassia constituents (cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model. When RAW264.7 macrophages were treated …
Cinnamic acid and autophagy
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WebTreatment with 100 ppm of cinnamic acid resulted in a significant reduction of melanin production in the melan-a cells at 29.0%. This compound also exhibited a potent inhibitory effect on tyrosinase activity and reduced tyrosinase expression in the melan-a cells. Moreover, cinnamic acid exhibited depigmenting activity on the UV-B-induced ... WebCinnamic acid (C9 H 8 O 2) is an organic acid isolated from cinnamon bark and generally used as a common food additive being antimicrobial against common postharvest …
WebMelanoma is the deadliest type of skin cancer, with about 61,000 deaths annually worldwide. Late diagnosis increases mortality rates due to melanoma’s capacity to metastasise rapidly and patients’ resistance to the available conventional therapies. Consequently, the interest in natural products as a strategy for drug discovery has been … WebOral administration of cinnamic acid protected tyrosine hydroxylase (TH)-positive dopaminergic neurons in the substantia nigra pars compacta (SNpc) and TH fibers in the striatum of MPTP-insulted mice.
WebJul 1, 2024 · Cinnamic acid, 4-position cinnamic acid with substituent and 5-fluorocinnamic acid were coupled with the 3-OH position of 2a-d to obtain esters 3a-p in 1-ethyl-(3-(3-dimethiylamino) propyl)-carbodiimide hydrochloride ... Autophagy, as a lysosomal degradation pathway, which is considered to be a third mode of cell death … WebApr 10, 2024 · Zhou et al. developed the new agent Ir-valproic acid which managed to inhibit HDAC6 in HeLa cells and, consecutively, switch the mode of cell death (apoptosis vs. autophagy) . In 2012, Feng et al. combined valproic acid with all- trans retinoic acid (ATRA), which led to the hyperacetylation of histone H3.
WebCinnamic acid is an organic acid occurring naturally in plants that has low toxicity and a broad spectrum of biological activities. In the search for novel pharmacologically active compounds, cinnamic acid derivatives are important and promising compounds with high potential for development into drugs.
WebJan 19, 2016 · Hydroxycinnamates are a class of phenolic compounds that have a C6-C3 carbon backbone. Hydroxycinnamic acids are derived from cinnamic acid via hydroxylation or methylation and are found in foods such as pears, coffee beans, and dandelions. They are involved in protection against chemotherapy side effects and the prevention of … how to share iphoto album with androidWebJan 11, 2024 · Cinnamic acid (AC) and cinnamic aldehyde (AL) are two chemicals enriched in cinnamon and have been previously proved to improve glucolipid … notion exam trackerWebTherefore, calycosin-7-O-glucoside, calycosin, paeoniflorin, 4-hydroxycinnamic acid, formononetin, and wogonoside may be the active ingredients of HGWD for promoting nerve function recovery after stroke. Figure 7 Effects of the identified compounds on the survival rate of OGD/R-treated HT22 cells. how to share iphoto albumWebCinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β-unsaturation and the reactions of the carboxylic acid functionality. Owing to these chemical aspects cinnamic acid derivatives received much … how to share iphone picturesWebJul 18, 2024 · A cytotoxicity assay performed with pure rosmarinic acid on MKN45 human gastric cancer cells reported an IC 50 of 240.2 μM and the suppression of cytokines, including IL-6, IL-1β, TNF-α, and TNFsR-1. 55 Ursolic acid is well recognized as a suppressor of angiogenesis by inhibiting IL-8 in hepatocellular carcinoma and IL-6 in … how to share iphoto slideshowWebAug 9, 2024 · The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional g … how to share iphoto slideshow on facebookWebPrevious studies reported disrupted hepatic function and structure following the administration of cyclosporine A (CsA) in humans and animals. Recently, we found that avocado seeds (AvS) ameliorated CsA-induced nephrotoxicity in rats. As a continuation, herein we checked whether AvS could also attenuate CsA-induced hepatotoxicity in rats. … notion exchange rate