Bitler and claudin-4
WebMichael Koval, in Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease, 2024. 1.4.2.2 Claudin-4. Claudin-4 also is prominently expressed throughout the lung … WebClaudin-4 was thus considered very useful marker for distinguishing mesothelioma and adenocarcinoma, even if histological specimens are small, as in biopsies that contain limited numbers of tumor cells. However, it should be mentioned that claudin-4 has a limit in discrimination between squamous cell carcinoma from mesothelioma.
Bitler and claudin-4
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WebJul 7, 2024 · In addition, some data have demonstrated that claudin delocalization contributes to cancer hallmarks. For instance, activated ephrin receptor A2 phosphorylates the tyrosine residue of claudin-4, decreasing its association with ZO-1 and leading to claudin-4 accumulation in the cytoplasm, which decreases the integration of claudin-4 …
WebAug 1, 2024 · Objectives: Claudin-4 is aberrantly expressed in nearly 70% of all ovarian cancer tumors, and increased claudin-4 expression conveys a worse overall survival. Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic option for patients with ovarian cancer. PARP inhibitors exploit deficiencies in DNA damage repair (e.g., BRCA … WebSep 24, 2024 · The increase of claudin-4 in rat colon after chronic DMH exposure was consistent with the acute effect of DMH on IPEC-J2 cells, which may indicate an essential role of this protein in colorectal cancer development. ... P.G.; Galimanis, C.E.; Bitler, B.G.; Behbakht, K.; Baumgartner, H.K. Ovarian Tumor Cell Expression of Claudin-4 Reduces ...
WebKirker Butler. Hartford, Kentucky. Occupation. Writer. Years active. 1999-present. Website. kirkerbutler.com. Kirker Butler is an American writer, who has written and produced … WebClaudin-4 phosphorylated on tyrosine 208 does not overlap with non-phosphorylated claudin-4. ... This work was supported by The Department of Defense (Bitler, OC170228, OC200302, OC200225), The American Cancer Society (Bitler, RSG-19-129-01-DDC), NIH/NCI (Bitler, R37CA261987). The imaging experiments were performed in the …
WebAug 4, 2024 · Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability. Claudin-4 was the first claudin whose involvement in the TJ permeability in cultured cells was directly demonstrated, but …
WebNov 1, 2005 · Abstract. The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently … portobello shop ms barcelonaWebClaudin-1 and -3 expression levels were unchanged in controls and active UC. In active UC claudin-2 mRNA was increased, whereas claudin-4 and -7 mRNA were decreased. … portobello shop americanaWebMay 15, 2004 · By contrast, when claudin-3 is introduced into MDCK I cells, no change in their TER is detected. Claudin-2 thus markedly decreases the `tightness' of individual claudin-1/claudin-4-based TJ strands, providing support for the hypothesis that different combinations of claudins determine the barrier properties of individual TJ strands. portobello shop morumbiWebAug 15, 2005 · Abstract. Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human ovarian surface … optische blurritisWebJul 21, 2024 · Claudin-4, a protein with the structure of classic claudins most often found in cell-cell junctions, is frequently overexpressed in epithelial cancers; it is le. ... (Bitler, … optische firmenWebHere, overexpressed claudin-4 in the jejunum and colon, coinciding with a caspase-3 decrease 72 h after 10-Gy IR exposure, can reflect the role of claudin-4 in apoptosis … optische buchse tonproblemeWebMar 18, 2024 · The role of claudins in maintaining cell barrier as well as small ions and neutral solutes selective transport is crucial: experimental claudins knockout models lacking CLDN1 and CLDN5 are lethal [14,15].Overexpression of claudin-1, claudin-4, claudin-5, and claudin-7 increase transepithelial resistance (TER), whereas claudin-2 and claudin … optische effecten